Genome sequence analysis - Parabricks | Software | Solutions

From DNA to RNA, NVIDIA Clara™ Parabricks provide powerful acceleration for primary, secondary and tertiary analyses of genomic data.
This is turnkey software designed for local or cloud systems in high-throughput labs, and a technology stack that enables developers to create powerful computational tools for genomics.

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ACCELERATE GENOME ANALYSIS

CLARA PARABRICKS PIPELINES

NVIDIA Clara Parabricks pipelines are based on the Broad Institute's Genome Analysis Toolkit (GATK). Clara Parabricks is an out-of-the-box, GPU-accelerated software suite for:

DNA germline -Variant determination in population genomics
DNA-somatic Variant determination for cancer genomics and tumour mutational burden (TMB)
RNA-Sequencing projects from the whole transcriptome to single cell analysis
DeepVariant from Google, which enables variant determination with the help of a Deep Neural Network

Clara Parabricks pipelines are optimised for speed, precision and scalability, can run GATK4.1 best practices and are fully configurable. Thus, users can choose.

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UNMATCHED PERFORMANCE AND THROUGHPUT IN SECONDARY ANALYSIS

Clara Parabricks pipelines run on NVIDIA A100 Tensor Core GPUs and offer unprecedented performance, reducing DNA germline variant analysis time to 23 minutes. GPU acceleration also allows users to benefit from up to 50 per cent lower cloud computing costs compared to CPU-only solutions.

PERFORMANCE COMPARISON

Consistent secondary germline analysis

Data was generated using publicly available data on NA 12878, data discounted for 30x coverage DGX A100 with 320 GB memory was used for the runtime of 23 minutes. Native GATK4.1 values were generated using 32 vCPU [3.1 GHz Intel Xeon® Platinum 8175M] with 128 GB RAM.

Clara Parabricks-Toolkit

Das NVIDIA Clara Parabricks-Toolkit ist eine Sammlung grafikprozessorbeschleunigter Edge-Bibliotheken, Referenzanwendungen sowie Open-Source-Anwendungen. Es wurde für Entwickler entworfen, die KI-gestützte Workflows für die Genomanalyse erstellen. Mit dem Toolkit können sie die Zuordnung, die Ausrichtung und die Aufbereitung für neue Genomassemblierungen optimieren und die Auflösung einzelliger Epigenomen verbessern.

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REASONS FOR USING CLARA PARABRICKS PIPELINES

EASY ENTRY

Clara Parabricks pipelines can be set up within 10 minutes. Watch this step-by-step instructional video and experience high-throughput analysis for DNA and RNA sequencing projects.

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FASTER DIAGNOSIS.
BETTER TREATMENT RESULTS

Clara Parabricks pipelines deliver results faster than non-GPU accelerated solutions. Learn how TGEN uses same-day results to examine the whole genome sequence of healthy and diseased cells to determine the most effective therapy, individualised for each patient.

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BETTER GENOMIC KNOWLEDGE

Clara Parabricks pipelines running in the cloud or locally can help researchers understand viral pandemics like COVID-19 faster - from virus evolution to human response to human vulnerability.

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