Faster and more accurate genomic analysis with NVIDIA Clara™ Parabricks. Clara Parabricks is a GPU-accelerated application framework for computational genomics. It delivers accurate and accelerated analysis of next-generation sequencing data for researchers and clinical teams, as well as medical and sequencing centers for genetic diseases and cancer.
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High throughput

Process up to 60 copy genomes per day on a single server.

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Increased accuracy

You don't have to sacrifice accuracy to reduce turnaround time. A range of germline and somatic detectors are available.

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Flexible pipelines

Create custom accelerated pipelines by configuring over 33 tools for each specific pipeline or application requirement.

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30 to 60 times faster

Reduce computing costs by up to 50 percent by working 30 to 60 times faster than CPU-only solutions.


From FASTQ to Binary Alignment Map (BAM) to VCF, NVIDIA is accelerating genomic analysis for somatic, germline, and structural variant workflows, as well as improving sequencer speed and consensus read base call accuracy.
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Next-generation sequencing on-site or in the cloud

A minimum of two GPUs are required to run NVIDIA Clara Parabricks. Local licenses are annual GPU-based subscriptions that include full access to all pipelines in the NVIDIA Clara Parabricks software suite.
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Local solutions

Clara Parabricks runs on an NVIDIA DGX™ A100 and analyzes up to 25,000 complete genomes per year (30X coverage) using the Broad Institute's Genomic Analysis Toolkit (GATK). Throughput scales linearly beyond a single DGX A100.
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In the cloud

In the cloud, time is money. Choose from a range of GPU instances that can analyze genomes in minutes. For easy deployment on AWS, Clara Parabricks are available in an Amazon Machine Image (AMI) for immediate use.
With the NVIDIA AI Enterprise suite and NVIDIA's most advancedGPUs anddata processing units (DPUs), VMware customers can securely run modern, accelerated workloads alongside existing enterprise applications onNVIDIA-certified systems, from on-premises data centers to hybrid clouds, from virtual machines to containers.

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How Clara Parabricks has a real impact


Regeneron Genetics Center

Learn how Regeneron uses DeepVariant with Clara Parabricks to generate scalable, high-quality data that can be replicated across the genomics community.

National Biobank of Thailand (NBT)

Using NVIDIA DGX A100 and Clara Parabricks, NBT reduced whole genome sequence data processing by four months and individual user processing time from over 30 hours to just 1 to 2 hours.
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Translational Genomics Research Institute (TGen)

Using NVIDIA Clara Parabricks and NVIDIA V100 Tensor compute unit GPUs, TGen accelerated genomic sequencing analysis 6-fold to determine personalized treatments for children with rare neurological disorders.
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Washington University in Saint Louis (WUSTL)

Integrating GPU-based steps with NVIDIA Clara Parabricks enabled WUSTL's Tychele Turner to dramatically reduce the runtime for De Novo variant calls.